Cajun Chicken Alfredo Pasta

Featured in: Hearty Family Meals

This Cajun Chicken Alfredo combines tender, spice-rubbed chicken breasts with a luxurious homemade Alfredo sauce featuring butter, garlic, heavy cream, and Parmesan cheese. Ready in 40 minutes, this fusion dish serves four and delivers bold Cajun heat balanced with Italian comfort. The silky sauce clings beautifully to fettuccine, creating a satisfying main course that impresses without complicated techniques.

Updated on Sun, 18 Jan 2026 15:34:00 GMT
Golden-brown Cajun chicken slices rest atop creamy fettuccine Alfredo in a rustic white bowl, garnished with fresh parsley and extra Parmesan. Pin It
Golden-brown Cajun chicken slices rest atop creamy fettuccine Alfredo in a rustic white bowl, garnished with fresh parsley and extra Parmesan. | yummyhrira.com

My skillet was still warm from dinner when a friend texted asking how to make pasta feel special on a Tuesday. I thought about the nights when I craved both comfort and a little fire, and this dish always delivered. The trick is letting the Cajun spice bloom in the pan before it ever touches the cream. It's not quite Italian, not quite Southern, but somehow it feels like both are having a conversation in your kitchen. That balance is what keeps me coming back.

I made this for my sister after she moved into her first apartment, and she called it restaurant-quality, which made me laugh because I'd just learned not to boil the cream too hard. We sat on her floor with mismatched bowls, twirling fettuccine and talking about nothing important. She's made it a dozen times since, always texting me when the sauce breaks or the chicken sticks. Those small panics are part of learning, and now she doesn't need my help anymore.

Ingredients

  • Boneless, skinless chicken breasts: They soak up the Cajun seasoning beautifully, and slicing them after cooking keeps them juicy instead of dry.
  • Cajun seasoning: This is where the personality lives, so use a blend you actually like or make your own with paprika, garlic powder, and cayenne.
  • Fettuccine or linguine: The flat noodles grab onto the sauce better than thinner pasta, and they feel more luxurious in the mouth.
  • Heavy cream: No shortcuts here, the richness is essential to balance the spice and create that velvety coating.
  • Parmesan cheese: Freshly grated melts smoothly into the sauce, while pre-shredded can clump or taste waxy.
  • Garlic: Sauteing it in butter before adding cream builds a sweet, mellow base that supports everything else.
  • Red pepper flakes: Optional, but they add a second layer of heat that lingers differently than Cajun spice.
  • Fresh parsley: A handful at the end brightens the whole dish and cuts through the richness visually and flavor-wise.

Instructions

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Cook the pasta:
Boil salted water and cook the fettuccine until it still has a slight bite, then save half a cup of that starchy water before draining. That pasta water is liquid gold for loosening the sauce later.
Season and sear the chicken:
Pat the chicken dry so the seasoning sticks, then rub it all over with Cajun spice before hitting the hot skillet. Sear each side until golden and the internal temperature reads 165°F, then let it rest before slicing so the juices stay inside.
Build the Alfredo base:
Melt butter in the same skillet and let the garlic sizzle for just 30 seconds, you want fragrance, not browning. Pour in the cream and whisk gently as it warms, keeping the heat medium so it thickens without breaking.
Finish the sauce:
Stir in Parmesan, black pepper, salt, and red pepper flakes if you like heat, and let it simmer until it coats the back of a spoon. If it gets too thick, add reserved pasta water a little at a time until it flows smoothly.
Toss and serve:
Add the drained pasta to the skillet and toss until every strand is glossy, then layer in the sliced chicken and toss again. Serve immediately with parsley and extra Parmesan on top.
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A close-up of fork-twirled Cajun Chicken Alfredo, highlighting the rich, velvety sauce and spicy seasoning on tender pasta and sliced chicken. Pin It
A close-up of fork-twirled Cajun Chicken Alfredo, highlighting the rich, velvety sauce and spicy seasoning on tender pasta and sliced chicken. | yummyhrira.com

One night I served this to friends who claimed they didn't like spicy food, and they went quiet for the first few bites before asking for seconds. The cream tempers the heat just enough that it feels warm instead of aggressive. It reminded me that good food can change minds without saying a word.

Adjusting the Heat

The beauty of this dish is that you control the fire. Start with less Cajun seasoning if you're unsure, you can always add more to the chicken or sprinkle it over the finished plate. I've made this for kids by cutting the seasoning in half and skipping the red pepper flakes entirely, and they still loved it. On the other hand, if you want it bolder, bloom extra Cajun spice in the butter before adding the cream. Taste as you go, and trust your instincts.

Making It Your Own

I've stirred in sauteed bell peppers when I had them sitting in the fridge, and they added a sweet crunch that played nicely with the spice. Spinach wilts beautifully into the hot sauce at the last minute if you want something green. Shrimp works just as well as chicken, and cooks even faster, making this a 30-minute meal. Sometimes I swap the chicken for crispy tofu when I'm cooking for my vegetarian neighbor, and she swears it's just as satisfying.

Storing and Reheating

Leftovers keep in the fridge for up to three days, and I reheat them gently in a skillet with a splash of milk or cream to bring the sauce back to life. The microwave works in a pinch, but the stovetop gives you more control and keeps the pasta from turning rubbery. I've even eaten this cold straight from the container during a busy morning, and it still tasted like a good decision.

  • Store in an airtight container to keep the garlic from perfuming your entire fridge.
  • If the sauce separates after reheating, whisk in a tablespoon of warm water or cream and it will come back together.
  • Freeze individual portions for up to a month, but know the texture of the cream may change slightly after thawing.
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Served steaming on a wooden table, this Cajun Chicken Alfredo dish features vibrant green parsley and golden noodles for a comforting meal. Pin It
Served steaming on a wooden table, this Cajun Chicken Alfredo dish features vibrant green parsley and golden noodles for a comforting meal. | yummyhrira.com

This dish has become my answer to the question of what to cook when I want to feel like I'm treating myself without leaving the house. It's rich, bold, and forgiving, which is exactly what good food should be.

Recipe FAQs

Can I use boneless chicken thighs instead of breasts?

Yes, boneless chicken thighs work wonderfully. They're more forgiving and stay juicier. Increase cooking time slightly to ensure they reach 165°F internally. Thighs add rich flavor that complements the Cajun seasoning beautifully.

How do I prevent the Alfredo sauce from breaking or curdling?

Keep the heat at medium and avoid boiling. Whisk constantly when adding cream and maintain gentle simmering. If the sauce seems too thick, gradually add reserved pasta water rather than more cream. Ensure butter is fully melted before adding cream.

What pasta shapes work best with this dish?

Fettuccine and linguine are ideal for clinging to the creamy sauce. Pappardelle also works well. Avoid very thin pastas like angel hair, which may get lost in the sauce. Shapes with ridges help capture the Alfredo better.

Can I make this dish ahead of time?

Prepare the chicken and sauce components separately ahead of time, but combine everything fresh just before serving. Alfredo sauce is best enjoyed immediately. You can store leftover portions refrigerated for two days and gently reheat with a splash of cream.

What wine pairs well with this meal?

Crisp white wines like Sauvignon Blanc complement the rich, spicy flavors perfectly. Pinot Grigio also works well. The acidity cuts through the creamy sauce while the wine's lightness balances the Cajun heat beautifully.

How can I adjust the spice level?

Add more or less Cajun seasoning to the chicken based on preference. Red pepper flakes in the sauce provide additional heat—start with less and taste as you go. Fresh jalapeños can be added to the sauce for more kick if desired.

Cajun Chicken Alfredo Pasta

Spicy Cajun-seasoned chicken combined with creamy Alfredo sauce and perfectly cooked pasta for a delicious Southern-Italian fusion dish.

Prep Duration
15 minutes
Cook Duration
25 minutes
Overall Time
40 minutes


Level Medium

Cuisine American Cajun-Italian Fusion

Makes 4 Portions

Diet Preferences None specified

What You Need

Chicken

01 2 large boneless, skinless chicken breasts
02 1 tablespoon Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 ounces fettuccine or linguine pasta

Alfredo Sauce

01 2 tablespoons unsalted butter
02 3 cloves garlic, minced
03 1½ cups heavy cream
04 1 cup freshly grated Parmesan cheese
05 ¼ teaspoon ground black pepper
06 ¼ teaspoon salt
07 ¼ teaspoon red pepper flakes, optional

Garnish

01 2 tablespoons chopped fresh parsley
02 Extra grated Parmesan for serving

Step-by-Step

Step 01

Cook the Pasta: Bring a large pot of salted water to a boil. Add fettuccine and cook according to package instructions until al dente. Reserve ½ cup pasta water and drain the remainder. Set aside.

Step 02

Prepare the Chicken: Pat chicken breasts dry and rub evenly with Cajun seasoning.

Step 03

Sear the Chicken: Heat olive oil in a large skillet over medium-high heat. Add chicken breasts and cook for 5-6 minutes per side until golden and cooked through, reaching an internal temperature of 165°F. Remove from skillet, rest for 2-3 minutes, then slice into strips.

Step 04

Prepare the Alfredo Sauce: In the same skillet over medium heat, melt butter. Add minced garlic and sauté for 30 seconds until fragrant. Pour in heavy cream, whisking constantly, and bring to a gentle simmer without boiling.

Step 05

Finish the Sauce: Stir in Parmesan cheese, black pepper, salt, and red pepper flakes if using. Simmer for 2-3 minutes until sauce thickens. If sauce is too thick, add reserved pasta water one tablespoon at a time.

Step 06

Combine Components: Add cooked pasta to the skillet and toss well to coat with Alfredo sauce. Add sliced Cajun chicken and toss again.

Step 07

Plate and Serve: Transfer to serving plates immediately and garnish with chopped parsley and extra Parmesan cheese.

Cooking Tools

  • Large pot
  • Large skillet
  • Tongs
  • Chef's knife
  • Cutting board
  • Measuring cups and spoons
  • Whisk

Allergy Details

Look at each ingredient for allergens. Not sure? Please check with your doctor.
  • Contains milk: heavy cream, butter, Parmesan cheese
  • Contains wheat: pasta
  • May contain eggs if using fresh pasta
  • Verify Cajun seasoning ingredient label for gluten or additional allergens

Nutrition Details (per serving)

This is for general reference. For health matters, turn to your doctor.
  • Calorie Count: 670
  • Fat Content: 34 grams
  • Carbohydrates: 54 grams
  • Proteins: 40 grams